Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -SGLT-1 (Sodium Glucose Transporter 1)

Anti -SGLT-1 (Sodium Glucose Transporter 1)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
The kidneys play a major role in the regulation of glucose levels. Kidneys filter approx. 180g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, Sodium glucoseco transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual member of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of approx 659-672 residues (calculated size of ~75kD). Both N and C-termini are predicted to be extracellualr. There is approx 60-70% homology between SGLT1-3. SGLTs transport a-methyl-D-glucoside (a-MDG), a non-metabolized model substrate, in Na-dependent manner. SGLT1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently.
Catalog #S1010-86H
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:5000 (ECL). Detects a band at ~70-77kD.
ELISA: 1:10,000-1:50,000. Coat ELISA plates at 1ug/ml with control peptide.
Optimal dilutions to be determined by the researcher.
Control PeptideS1010-86E: SGLT-1, Human, Control Peptide (Sodium Glucose Transporter 1)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Also AvailableS1010-86K: SGLT-1 (Sodium Glucose Transporter 1) Pab Rb xHu (Affinity purified antibody).
Mouse related productsS1010-86A: SGLT-1 (Sodium Glucose Transporter 1) Pab Rb xMo (antiserum)
S1010-86B: SGLT-1 (Sodium Glucose Transporter 1) Pab Rb xMo (affinity purified antibody)
S1010-86F: SGLT-1, Mouse (Sodium Glucose Transporter 1) (control peptide)
Rat related productsS1010-86C: SGLT-1, Rat (Sodium Glucose Transporter 1) (control peptide)
S1010-86D: SGLT-1 (Sodium Glucose Transporter 1) Pab Rb xRt (antiserum)
S1010-86G: SGLT-1 (Sodium Glucose Transporter 1) Pab Rb xRt (affinity purified antibody)
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to 16aa sequence from the C-terminal, cytoplasmic domain 6 of human SGLT-1 conjugated to KLH.
SpecificityRecognizes human SGLT-1. No significant sequence homology exists with other SGLTs. Species sequence homology (56%): mouse, rat. For mouse and rat, we recommend S1010-86D or S1010-86G.
Mouse related products
S1010-86ASGLT-1 (Sodium Glucose Transporter 1) Pab Rb xMo (antiserum)
S1010-86BSGLT-1 (Sodium Glucose Transporter 1) Pab Rb xMo (affinity purified antibody)
S1010-86FSGLT-1, Mouse (Sodium Glucose Transporter 1) (control peptide)
Rat related products
S1010-86CSGLT-1, Rat (Sodium Glucose Transporter 1) (control peptide)
S1010-86DSGLT-1 (Sodium Glucose Transporter 1) Pab Rb xRt (antiserum)
S1010-86GSGLT-1 (Sodium Glucose Transporter 1) Pab Rb xRt (affinity purified antibody)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links