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Anti -SGLT-2 (Sodium Glucose Transporter 2)
Anti -SGLT-2 (Sodium Glucose Transporter 2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| The kidneys play a major role in the regulation of glucose levels. Kidneys filter ~180g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, Sodium glucose co-transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). About 3 members of SGLTs (SGLT-1-3) have been cloned and characterized from various species. Individual member of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT-1-3 genes code for protein of ~659-672 residues (calculated size of ~75kD). Both N- and C-termini are predicted to be extracellular. There is ~60-70% homology between SGLT-1-3. SGLTs transport a-methyl-D-glucoside (a-MDG), a non-metabolized model substrate, in Na-dependent manner. SGLT-1 does not discriminate a-MDG, glucose, and galactose. SGLT-2/3 do not transport D-galactose efficiently. | | | Catalog # | S1010-87E | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plates at 1ug/ml. | | Western Blot: 1-10ug/ml using ECL. | | Optimal dilutions to be determined by the researcher. | | Recommended Control Peptide | S1010-87F: SGLT-2, Human, Control Peptide (Sodium Glucose Transporter 2) | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 01% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the 16aa sequence from the C-terminal, cytoplasmic domain 6 of human SGLT-2, conjugated to KLH. Species Sequence Homology | | Specificity | Recognizes human SGLT-2. No significant sequence homology exists with other SGLTs. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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