Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -SGLT-2 (Sodium Glucose Transporter 2)

Anti -SGLT-2 (Sodium Glucose Transporter 2)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
The kidneys play a major role in the regulation of glucose levels. Kidneys filter ~180g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, Sodium glucose co-transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). About 3 members of SGLTs (SGLT-1-3) have been cloned and characterized from various species. Individual member of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT-1-3 genes code for protein of ~659-672 residues (calculated size of ~75kD). Both N- and C-termini are predicted to be extracellular. There is ~60-70% homology between SGLT-1-3. SGLTs transport a-methyl-D-glucoside (a-MDG), a non-metabolized model substrate, in Na-dependent manner. SGLT-1 does not discriminate a-MDG, glucose, and galactose. SGLT-2/3 do not transport D-galactose efficiently.
Catalog #S1010-87E
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plates at 1ug/ml.
Western Blot: 1-10ug/ml using ECL.
Optimal dilutions to be determined by the researcher.
Recommended Control PeptideS1010-87F: SGLT-2, Human, Control Peptide (Sodium Glucose Transporter 2)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 01% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the 16aa sequence from the C-terminal, cytoplasmic domain 6 of human SGLT-2, conjugated to KLH. Species Sequence Homology
SpecificityRecognizes human SGLT-2. No significant sequence homology exists with other SGLTs.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links