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Anti -SGLT-3 (Sodium Glucose Transporter 3)
Anti -SGLT-3 (Sodium Glucose Transporter 3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| The kidneys play a major role in the regulation of glucose levels. Kidneys filter approx. 180 g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, Sodium glucose co transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual member of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of approx 659-672 residues (calculated size of ~75kD). Both N and C-termini are predicted to be extracellualr. There is approx 60-70% homology between SGLT1-3. SGLTs transport a-methyl-D-glucoside (a-MDG), a non-metabolized model substrate, in Na-dependent manner. SGLT1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently. | | | Catalog # | S1010-87L1 | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilutions | Western Blot: 1-10ug/ml using ECL | | ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plate at 1ug/ml | | Optimal dilutions to be determined by the researcher. | | Control Peptide | S1010-87L: SGLT-3, Mouse Control Peptide (Sodium Glucose Transporter 3). | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, .1% BSA | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | A synthetic peptide corresponding to 16aa near the N-terminal, cytoplasmic domain of mouse SGLT-3, conjugated to KLH. Species Sequence Homology: human and porcine ~37% | | Specificity | Recognizes mouse SGLT-3. No significant sequence homology exists with other SGLTs. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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