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You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -SGLT-3 (Sodium Glucose Transporter 3)

Anti -SGLT-3 (Sodium Glucose Transporter 3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
The kidneys play a major role in the regulation of glucose levels. Kidneys filter approx. 180 g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, Sodium glucose co transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual member of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of approx 659-672 residues (calculated size of ~75kD). Both N and C-termini are predicted to be extracellualr. There is approx 60-70% homology between SGLT1-3. SGLTs transport a-methyl-D-glucoside (a-MDG), a non-metabolized model substrate, in Na-dependent manner. SGLT1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently.
Catalog #S1010-87L1
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1-10ug/ml using ECL
ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plate at 1ug/ml
Optimal dilutions to be determined by the researcher.
Control PeptideS1010-87L: SGLT-3, Mouse Control Peptide (Sodium Glucose Transporter 3).
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, .1% BSA
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to 16aa near the N-terminal, cytoplasmic domain of mouse SGLT-3, conjugated to KLH. Species Sequence Homology: human and porcine ~37%
SpecificityRecognizes mouse SGLT-3. No significant sequence homology exists with other SGLTs.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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