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You are here:Home » Antibodies » Abs to Neuroscience » Anti -DLGAP1 (pan-SAPAP, DAP-1, Disks large-associated protein 1, Gkap, Guanylate kinase-associated protein, PSD-95/SAP90-binding protein 1, rGKAP, SAP90/PSD-95-associated protein 1, SAPAP1)

Anti -DLGAP1 (pan-SAPAP, DAP-1, Disks large-associated protein 1, Gkap, Guanylate
kinase-associated protein, PSD-95/SAP90-binding protein 1, rGKAP, SAP90/PSD-95-associated
protein 1, SAPAP1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IC
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or
mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are
classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels;
each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to
the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient
receptor potential channels (2). The SAPAP proteins are thought to be adaptor proteins that
also interact with different synaptic scaffolding proteins, cytoskeletal and signaling components (3, 4). SAPAP1, 2 and 4 mRNA are targeted to cell bodies, whereas SAPAP3 mRNA is detected mainly in cell bodies (3, 5).
Catalog #S1010-88A12
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot:1-10ug/ml
Immunocytochemistry:0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No10F766
HostMouse
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenFusion protein aa 772-992 (C-terminus) of rat SAPAP1 (also known as disks large-associated protein 1, guanylate kinase-associated
protein, GKAP, SAP90/PSD-95 associated/binding protein 1,
accession number P97836).
SpecificityRecognizes rat SAPAP1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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