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Anti -Shc (SHC-transforming Protein 1, SHC-transforming Protein 3, SHC-transforming Protein A, Src Homology 2 Domain-containing-transforming Protein C1, SH2 Domain Protein C1, SHC1, SHCA)
Anti -Shc (SHC-transforming Protein 1, SHC-transforming Protein 3, SHC-transforming
Protein A, Src Homology 2 Domain-containing-transforming Protein C1, SH2 Domain Protein
C1, SHC1, SHCA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Shc possesses SH2 and PTB domains. It serves a scaffolding function in signaling for a variety of receptor tyrosine kinases. Shc exists in p46, p52 and p66 isoforms. These isoforms are produced by using alternative translation initiation sites or a differentially spliced message. In response to extracellular signals, the SH2 and PTB domains of Shc interact with the activated receptors, leading to phosphorylation of Shc on three different tyrosine residues: Tyr239, Tyr240 and Tyr317. Grb2/Sos binds to Shc phosphorylated at these sites, activating the Ras/Raf/MAPK pathway. Both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development. | | | Catalog # | S1010-90M | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot:1:500-1:1,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to human Shc1 around the phosphorylation site of tyrosine 349 (H-Q-YP-Y-N). | | Specificity | Recognizes human Shc1. Species Cross-Reactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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