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You are here:Home » Antibodies » Antibodies-Protein Kinase Substrates » Anti -SH2 Domain Protein 2A (SH2D2A, Lck-associated Adapter Protein, Lad, Rlk/Itk-binding Protein, RIBP)

Anti -SH2 Domain Protein 2A (SH2D2A, Lck-associated Adapter Protein, Lad, Rlk/Itk-binding
Protein, RIBP)


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Clone Host Grade Applications
Polyclonal Sheep Affinity Purified B
RIBP (Rlk/Itk-binding protein; also SH2D2A, LAD/Lck-associated adapter protein, MEKK2-binding protein and TSAd) is a 45-47kD cytoplasmic adaptor protein. It is found in B cells, thymocytes, NK cells and T cells, and appears to be necessary for TCR-initiated proliferation, plus IL-2 and IFN-gamma secretion. This is likely to be a function of its association with MEKK2 near the T cell receptor interaction site. Mouse RIBP is 374aa in length and contains one SH2 domain (aa116-207), plus a Pro-rich region (aa267-308) that contains an SH3-binding motif (aa267-273). Phosphorylation may occur on Ser237, Ser316 and Tyr325. There is one alternative splice form termed LAD that shows a deletion of aa254-261. Over aa299-374, mouse RIBP shares 79% and 63% aa identity with rat and the presumed human RIBP ortholog (termed TSAd/SH2D2A), respectively.
Catalog #S1010-90P
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1ug/ml Detects a band at ~45kD.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS, 0.02% sodium azide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenPurified, E. coli-derived recombinant mouse RIBP (rmRIBP; aa299-374; Accession # Q9QXK9).
SpecificityRecognizes mouse SH2D2A. Species Crossreactivity: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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