Anti -Shc, phosphorylated (Tyr239, Tyr240) (SHC1, Src homology and collagen, Src homology
2, FLJ26504, p52SHC, p66SHC, SH2 domain protein C1, SHC, SHCA, SHC transforming protein 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
|
E B |
|
| The human Src homology and collagen (SHC) gene encodes for three proteins (p46, p52, p66). All three SHCs are known to be signaling adaptors that couple activated growth factor receptors to their signaling pathways. p52 and p46 are translated from the same mRNA using two different initiation codons while p66 is generated form a distinct mRNA. p52 and p46 are expressed in every cell type while p66 expression varies from cell type to cell type. Upon stimulation by tyrosine kinase receptors and cytoplasmic TKs, all three SHCs become phosphorylated. Once phosphorylated, p52, p46 and p66 recruit and form a stable complex with GRB2/SOS. p52 and p46 activate the Ras and MAP kinase pathway, while p66 is involved in a signal transduction pathway that regulates the cellular response to oxidative stress and life span. | | | Catalog # | S1010-92K | | Application(s) | ELISA, Western Blot | | Optimal conditions must be determined individually for each application. | | Positive Control included | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50?, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6D761 | | Host | Mouse | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. | | Immunogen | Synthetic peptide corresponding to aa 236-243 (D236HQpYpYNDF243) of shc phosphorylated at Tyr239 and Tyr240. | | | Specificity | Recognizes human, mouse, rat and canine shc phosphorylated at Tyr239/240. Does not crossreact with non-phosphorylated shc. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Shc, phosphorylated (Tyr239, Tyr240) (SHC1, Src homology and collagen, Src homology 2, FLJ26504, p52SHC, p66SHC, SH2 domain protein C1, SHC, SHCA, SHC transforming protein 1) |
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