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You are here:Home » Antibodies » Abs to Adapter Proteins » Anti -SHC, phosphorylated (Tyr239, Tyr240) (p52 SHC, p52SHC, p66 SHC, p66SHC, FLJ26504, MGC98812, p46, SH2 Domain Protein C1, SHC (Src Homology 2 Domain Containing) Transforming Protein 1, SHC-transforming Protein 1, SHC Transforming Protein, SHCA, SHC-A, Src H

Anti -SHC, phosphorylated (Tyr239, Tyr240) (p52 SHC, p52SHC, p66 SHC, p66SHC, FLJ26504,
MGC98812, p46, SH2 Domain Protein C1, SHC (Src Homology 2 Domain Containing) Transforming
Protein 1, SHC-transforming Protein 1, SHC Transforming Protein, SHCA, SHC-A, Src H

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
The human Src homology and collagen (SHC) gene encodes for three proteins (p46, p52, p66). All three SHC isoforms are known to be signaling adaptors that couple activated growth factor receptors to their signaling pathways.p52 and p46 are expressed in every cell type while p66 expression varies from cell type to cell type (1-3). Upon stimulation by tyrosine kinase receptors and cytoplasmic TKs, all three SHCs become phosphorylated. Once phosphorylated, p52, p46 and p66 recruit and form a stable complex with GRB2/SOS. p52 and p46 activate the Ras and MAP kinase pathway, while p66 is involved in a signal transduction pathway that regulates the cellular response to oxidative stress and life span (4-5).
Applications:
Suitable for use in Western Blot. Other applications not tested.
Catalog #S1010-92L2
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H508
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide and 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Tyrosine 239/240 of human SHC1.
SpecificityRecognizes human SHC1 when phosphorylated at Tyr239 and Tyr240.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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