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You are here:Home » Antibodies » Abs to Adapter Proteins » Anti -SHC1 (SHC-transforming Protein 1, SHC-transforming Protein A, Src Homology 2 Domain-containing-transforming Protein C1, SH2 Domain Protein C1, Shc, ShcA)

Anti -SHC1 (SHC-transforming Protein 1, SHC-transforming Protein A, Src Homology 2
Domain-containing-transforming Protein C1, SH2 Domain Protein C1, Shc, ShcA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH IF
The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then, a number of studies in multiple systems have implicated a role for Shc in many different types of signal transduction including growth factor, antigen, cytokine, G-protein, hormone, and integrin receptor signaling. In addition to the ubiquitous ShcA, there are two other shc gene products, ShcB and ShcC, which are predominantly expressed in neuronal cells. ShcA knockout mice are embryonic lethal and have clearly suggested an important role for ShcA in vivo. An important role for Shc in the activation of MAPK pathway has been established. Thus, Shc adapter proteins are critical components of signal transduction pathways involved in many different cellular processes.
Catalog #S1010-92N
ApplicationsSuitable for use in ELISA, Western Blot, Proximity Ligation Assay, Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1ug/ml
Immunofluorescence: 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG,k
Clone No3F4
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant corresponding to aa171-280 from human SHC1 with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human SHC1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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