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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -SETD8, NT (N-lysine Methyltransferase SETD8, H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, Lysine N-methyltransferase 5A, PR/SET Domain-containing Protein 07, PR-Set7, PR/SET07, SET Domain-containing Protein 8, KMT5A, PRSET7, SET07, SET8)

Anti -SETD8, NT (N-lysine Methyltransferase SETD8, H4-K20-HMTase SETD8, Histone-lysine
N-methyltransferase SETD8, Lysine N-methyltransferase 5A, PR/SET Domain-containing Protein
07, PR-Set7, PR/SET07, SET Domain-containing Protein 8, KMT5A, PRSET7, SET07, SET8)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
Catalog #S1012-28A1
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:100-1:500
Western Blot: 1:100-1:500
Immunohistochemistry (Formalin fixed paraffin embedded): 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No43AT551.86
HostMouse
SourceHuman
Concentration~0.25mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant GST fusion protein corresponding to the N-terminal region of human SET07.
SpecificityRecognizes human SETD8. Species sequence homology: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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