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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -SET07 (Histone H4-K20 Methyltransferase, H4-K20-HMTase, SET Domain-containing Protein 8, PR/SET Domain-containing Protein 07, PR/SET07, PR-Set7, KMT5A, Histone-lysine N-methyltransferase SETD8, H4-K20-HMTase SETD8, Lysine N-methyltransferase 5A, PRSET7, S

Anti -SET07 (Histone H4-K20 Methyltransferase, H4-K20-HMTase, SET Domain-containing
Protein 8, PR/SET Domain-containing Protein 07, PR/SET07, PR-Set7, KMT5A, Histone-lysine
N-methyltransferase SETD8, H4-K20-HMTase SETD8, Lysine N-methyltransferase 5A, PRSET7, S

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.
Catalog #S1012-28B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10i70
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenPurified recombinant GST fusion protein encoding N-terminal of human SET07.
SpecificityRecognizes human SET07. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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