protein tyrosine phosphatase-2, MGC14433, protein tyrosine phosphatase, non-receptor type 11, protein-tyrosine phosphatase 2C, Noonan syndrome 1, SH-PTP3, SH-PTP2, PTP-1D, SHP-2, PTP2C, BPTP3, NS1, CFC, protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1), SHP2, PTPN11

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.