Anti -SH2D1A (SH2 Domain Protein 1A, Duncan Disease SH2-protein, DSHP, EBVS, FLJ18687,
FLJ92177, HGNC:10820, IMD5, LYP, MTCP1, Signaling Lymphocyte Activation
Molecule-associated Protein, SLAM-associated Protein, SAP, T cell Signal Transduction
Molecule SAP, XL
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. | | | Catalog # | S1013-31E3 | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilutions | | | Peptide ELISA Titer: 1:16,000 | | Western Blot: 0.3-1ug/ml ~16kD band observed in Human Thymus lysates (calculated MW of 14.2xkD according to NP_002342.1). In transfected HEK293 transiently expressing SH2D1A a band of approx. 16kD is observed. This band is not observed in the non-transfected HEK293. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. | | Purity | Purified by peptide affinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-HKRYFRKIKN, from the internal region of human SH2D1A (NP_002342.1; NP_001108409.1). | | Specificity | Recognizes human SH2D1A. Species sequence homology: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | signaling lymphocyte activation molecule-associated protein, T cell signal transduction molecule SAP, SLAM-associated protein, FLJ92177, FLJ18687, RP5-1052M9.3, SLAM (signaling lymphocyte activation molecule) associated protein, SH2 domain protein 1A, XLP |
|
|
Questions or comments about this product? Inquire here. |
|
|
Download Specifications for Anti -SH2D1A (SH2 Domain Protein 1A, Duncan Disease SH2-protein, DSHP, EBVS, FLJ18687, FLJ92177, HGNC:10820, IMD5, LYP, MTCP1, Signaling Lymphocyte Activation Molecule-associated Protein, SLAM-associated Protein, SAP, T cell Signal Transduction Molecule SAP, XL |
External Links
|
