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You are here:Home » Antibodies » Abs to Signal Transduction » Anti -SH2D1A (SH2 Domain-containing Protein 1A, Duncan Disease SH2-protein, Signaling Lymphocytic Activation Molecule-associated Protein, SLAM-associated Protein, T-cell Signal Transduction Molecule SAP, DSHP, SAP)

Anti -SH2D1A (SH2 Domain-containing Protein 1A, Duncan Disease SH2-protein, Signaling
Lymphocytic Activation Molecule-associated Protein, SLAM-associated Protein, T-cell Signal
Transduction Molecule SAP, DSHP, SAP)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
SH2D1A is an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. This protein is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD) also known as Duncan disease. XLPD is characterized by a rare congenital immunodeficiency following Epstein-Barr virus (EBV) infection.
Catalog #S1013-31F1A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.2-0.6ug/ml, observed in human lymph node lysates on ~16kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-QYPVEKKSSARSTQ, from human SH2D1A, at the internal region of the protein (NP_002342.1, NP_001108409.1).
SpecificityRecognizes human SH2D1A. Species sequence homology: Porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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