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You are here:Home » Antibodies » Abs to Signal Transduction » Anti -SH3BP1 (SH3 Domain-binding Protein 1, SH3-domain Binding Protein 1, 3BP-1)

Anti -SH3BP1 (SH3 Domain-binding Protein 1, SH3-domain Binding Protein 1, 3BP-1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
Catalog #S1013-31FC
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:16,000
Western Blot: 1-3ug/ml, observed in human lung and kidney lysates on ~70kD bands
Immunohistochemistry (Paraffin): 0.3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-PQPRPRSLASETN, from human SH3BP1, at C-terminal (NP_061830.3).
SpecificityRecognizes human SH3BP1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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