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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -SIAH1 (Seven in Absentia Homolog 1 (Drosophila), SIAH 1, Siah-1, Siah-1a, hSIAH1, HUMSIAH, Ubiquitin Ligase SIAH1)

Anti -SIAH1 (Seven in Absentia Homolog 1 (Drosophila), SIAH 1, Siah-1, Siah-1a, hSIAH1,
HUMSIAH, Ubiquitin Ligase SIAH1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Catalog #S1013-31L6
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide SRQTATALPTGTSKC, representing the N-Terminus of the human protein sequence according to NP_003022.3; NP_001006611.1.
SpecificitySpecies Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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