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Anti -Siglec 7 (Sialic Acid-binding Immunoglobulin-like Lectin, CDw328)
Anti -Siglec 7 (Sialic Acid-binding Immunoglobulin-like Lectin, CDw328)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
IH FC |
|
| Siglec 7 is a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase. Siglec 7 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage. | | | Catalog # | S1013-60P | | Applications | Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Flow Cytometry: 1:100-1:200; 10ul labels 1x10e6 cells in 100ul. | | Immunohistochemistry (Frozen): 1:100 | | Optimal dilutions to be determined by the researcher. | | IHC Positive Control Tissue | Frozen tonsil | | Recommended Negative Control | I1904-78R: IgG1 Murine Negative Control | | Hybridoma | X63-Ag8.653 myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9A202 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Monocyte-derived dendritic cells. | | Specificity | Recognizes human Siglec 7. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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