Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Antibodies-Lectins » Anti -Siglec 8, CT (Sialic Acid-binding Ig-like Lectin 8, Siglec 8, Sialoadhesin Family Member 2, SAF-2, CDw329, CD329, SAF2)

Anti -Siglec 8, CT (Sialic Acid-binding Ig-like Lectin 8, Siglec 8, Sialoadhesin Family
Member 2, SAF-2, CDw329, CD329, SAF2)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B IH
SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
Catalog #S1013-61B
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by ammonium sulfate precipitation
ImmunogenKLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 373-406 in the C-terminal region of human SIGLEC8, UniProt Accession #Q9NYZ4.
SpecificityRecognizes human SIGLEC8. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links