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You are here:Home » Antibodies » Abs to Lectins » Anti -SIGLEC12, CT (Sialic Acid-binding Ig-like Lectin 12, Siglec-12, Sialic Acid-binding Ig-like Lectin-Like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG, UNQ9215/PRO34042)

Anti -SIGLEC12, CT (Sialic Acid-binding Ig-like Lectin 12, Siglec-12, Sialic Acid-binding
Ig-like Lectin-Like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG, UNQ9215/PRO34042)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.
Catalog #S1013-66B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide selected from the C-terminal region of human SIGLEC12 (KLH).
SpecificityRecognizes human SIGLEC12. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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