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You are here:Home » Antibodies » Abs to Lectins » Anti -Siglec 12 (Sialic Acid-binding Ig-like Lectin 12, Siglec 12, Sialic Acid-binding Ig-like Lectin-Like 1, Siglec L1, Siglec 12, Siglec L1, SLG, UNQ9215/PRO34042)

Anti -Siglec 12 (Sialic Acid-binding Ig-like Lectin 12, Siglec 12, Sialic Acid-binding
Ig-like Lectin-Like 1, Siglec L1, Siglec 12, Siglec L1, SLG, UNQ9215/PRO34042)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.
Catalog #S1013-66E
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:128,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-EAIGYEYSEINIPK, from SIGLECL1, at C-terminal (NP_201586.1, NP_443729.1).
SpecificityRecognizes SIGLECL1. Species sequence homology: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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