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You are here:Home » Antibodies » Antibodies-Lectins » Anti -Siglec 16 (Sialic Acid-binding Ig-like Lectin 16, Siglec 16, Siglec P16, Siglec P16)

Anti -Siglec 16 (Sialic Acid-binding Ig-like Lectin 16, Siglec 16, Siglec P16, Siglec P16)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
Siglec-16 is a 58-60kD member of the CD33-related SIGLEC family of proteins. It is expressed on macrophages and microglia, and based on Siglec-11, likely binds to an a 2,8-linked sialic acid motif. Although Siglec-16 is assumed to have arisen from a Siglec-11 gene duplication and conversion, it is not an inhibitory receptor but an activating one, and possesses a transmembrane (TM) Lys that interacts with DAP12. Mature human Siglec-16 is a 465aa type I TM glycoprotein. It contains a 418aa extracellular region aa17-434 that shows one V-type aa 19-122 plus three C2-type aa147-424 Ig-like domains, and a short 26aa cytoplasmic tail. Notably, Siglec-16 exists as a pseudogene in ~50% of surveyed population. There is no Siglec-16 counterpart in either rodent or distant primate such as Rhesus monkey. The extracellular domain (ECD) of human Siglec-16 shares 94% aa identity with the ECD of human Siglec-11.
Catalog #S1013-67T
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 2.5ug labels 10e6 cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No12K176
Concentration~0.5mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenSynthetic peptide PPARLSWTWGEQTVGPSQPSDPGVLQLPRV corresponding to aa369-398 from human Siglec-16.
SpecificityRecognizes human Siglec-16.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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