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You are here:Home » Antibodies » Abs to Lectins » Anti -Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (SIGN-R1)

Anti -Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (SIGN-R1)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified IH FC
Catalog #S1013-69
ApplicationsSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: Frozen 1:25-1:50.
Optimal dilutions to be determined by the researcher.
HybridomaHybridization of P3-X63-Ag8.563 myeloma cells with spleen cells from immunized rats.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgM
Clone No8J189
HostRat
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide
PurityPurified by ammonium sulfate precipitation.
ImmunogenIsolated C3H thymic stromal cells.
SpecificityRecognizes mouse SIGN-R1, a C-type lectin that has been identified as a murine homolog of the human CD-SIGN related molecule, L-SIGN. Mouse SIGN-R1 is specifically expressed on marginal zone macrophages in the spleen, medullary and subcapsular sinus macrophages in the lymph nodes, and at lower levels on liver sinusoidal endothelial cells. SIGN-R1 has not been detected on murine dendritic cell populations. Blocks the uptake of neutral polysaccharides by macrophages.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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