Anti -SIRP alpha, CT (Signal Regulatory Protein alpha, SIRPalpha, SIRPA, SIRP,
Signal-regulatory Protein alpha-1, Sirp-alpha-1, Signal-regulatory Protein alpha-2,
Sirp-alpha-2, Signal-regulatory Protein alpha-3, Sirp-alpha-3, Brain Ig-like Molecule with
Tyrosin
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
E B IC |
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| Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRP-a, SHPS-1, MyD-1, BIT and p84. SIRP-a is a new gene family containing at least fifteen members. SIRP-a is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRP-a has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes. | | | Catalog # | S1013-86Z5 | | Applications | Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | THP-1 cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified | | Immunogen | Synthetic peptide corresponding to aa near the C-terminus of human SIRP-a1. | | Specificity | Recognizes human SIRP-a. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -SIRP alpha, CT (Signal Regulatory Protein alpha, SIRPalpha, SIRPA, SIRP, Signal-regulatory Protein alpha-1, Sirp-alpha-1, Signal-regulatory Protein alpha-2, Sirp-alpha-2, Signal-regulatory Protein alpha-3, Sirp-alpha-3, Brain Ig-like Molecule with Tyrosin |
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