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You are here:Home » Antibodies » Antibodies-Protein Kinase Substrates » Anti -SIRP, alpha1 (SIRPa, Signal Regulatory Protein, SHPS-1, BIT, p84, CD172a)

Anti -SIRP, alpha1 (SIRPa, Signal Regulatory Protein, SHPS-1, BIT, p84, CD172a)


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Clone Host Grade Applications
Polyclonal Rabbit Highly Purified B
Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 may serve as both negative or positive regulators in the intracellular signaling pathways. They are critical in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. Recently identified was a novel SHP-2 associated glycosylated receptor-like protein from human, rat, mouse and cattle by several labs and was designated SIRP-1alpha (1), SHPS-1 (2,3), MyD-1 (4), BIT (5,6), p84 (7), and MFR (8). SHPS-1 is a member of a new gene family called the signal regulatory proteins of which there are at least fifteen members. SHPS-1 is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR, and src, a specific docking protein for SHP-2 (1,2,5,9). SHPS-1 has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes (1,2,5,9). The mRNA of SHPS-1 is predominantly expressed in hematopoietic cells (2,3).
Western Blot (Colorimetric): 4ug/ml
Optimal dilutions to be determined by researcher.
Catalog #S1013-87F
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.2, containing 0.02% sodium azide. This antibody is supplied as an IgG fraction.
PurityChromatographically purified
ImmunogenA 17 residue synthetic peptide KPEPSFSEYASVQVPRK based on
the carboxy terminus of human SHPS-1/SIRP-1alpha (residues 487-503) was synthesized and the peptide coupled to KLH. The sequence differs from those of mouse, rat, and bovine by one amino acid.
SpecificityDetects bands ranging from 80-95kD, corresponding to the many splice variants of SHPS-1 on SDS-PAGE immunoblots, in human cell lysates and in mouse, rat and bovine brain tissue extracts. The antibody specificity is confirmed in specific peptide inhibition immunoblotting studies
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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