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You are here:Home » Antibodies » Abs to Sirtuins » Anti -SIRT 5 (Sirtuin 5, Sirtuin-5, Sirtuin Type 5, NAD-dependent Deacetylase Sirtuin 5, Silent Mating Type Information Regulation 2 (S. cerevisiae) Homolog 5, Sir2-like 5, SIR2L5)

Anti -SIRT 5 (Sirtuin 5, Sirtuin-5, Sirtuin Type 5, NAD-dependent Deacetylase Sirtuin 5,
Silent Mating Type Information Regulation 2 (S. cerevisiae) Homolog 5, Sir2-like 5,
SIR2L5)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
Catalog #S1013-88J1
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5i85
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 40% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenOvalbumin-conjugated synthetic peptide corresponding to N-terminal aa1-50 of human silent information regulator 2 homolog (Sirt5)
SpecificityRecognizes human Sirt5, a NAD-dependent deacetylase, protein involved in diverse processes ranging from regulation of gene silencing to DNA damage response in mammalian cells.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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