You are here:Home
»
Antibodies
»
Abs to Sirtuins
»
Anti -SIRT 5 (Sirtuin 5, Sirtuin-5, Sirtuin Type 5, NAD-dependent Deacetylase Sirtuin 5, Silent Mating Type Information Regulation 2 (S. cerevisiae) Homolog 5, Sir2-like 5, SIR2L5)
Anti -SIRT 5 (Sirtuin 5, Sirtuin-5, Sirtuin Type 5, NAD-dependent Deacetylase Sirtuin 5,
Silent Mating Type Information Regulation 2 (S. cerevisiae) Homolog 5, Sir2-like 5,
SIR2L5)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones. | | | Catalog # | S1013-88J3 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | A synthetic peptide corresponding to amino acids 30-46 of human SIRT5 was used as immunogen. | | Specificity | Species Crossreactivity: Human, Mouse, Rat | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
