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You are here:Home » Antibodies » Abs to Sirtuins » Anti -SIRT 5 (Sirtuin 5, Sirtuin-5, Sirtuin Type 5, NAD-dependent Deacetylase Sirtuin 5, Silent Mating Type Information Regulation 2 (S. cerevisiae) Homolog 5, Sir2-like 5, SIR2L5)

Anti -SIRT 5 (Sirtuin 5, Sirtuin-5, Sirtuin Type 5, NAD-dependent Deacetylase Sirtuin 5,
Silent Mating Type Information Regulation 2 (S. cerevisiae) Homolog 5, Sir2-like 5,
SIR2L5)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
Catalog #S1013-88J3
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to amino acids 30-46 of human SIRT5 was used as immunogen.
SpecificitySpecies Crossreactivity: Human, Mouse, Rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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