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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -SKI (Sarcoma Viral Oncogene Homolog, Avian, c-SKI, SKV, v-Ski)

Anti -SKI (Sarcoma Viral Oncogene Homolog, Avian, c-SKI, SKV, v-Ski)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IC
SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.
Catalog #S1013-89N
ApplicationsSuitable for use in Immunocytochemistry, Immunoprecipitation, and Western Blot. Other applications not tested.
Recommended DilutionImmunocytochemistry: 1-10ug/ml
Western Blot: 1-5ug/ml
Immunoprecipitation: 1-5ug
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9L649
HostMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.4. No preservative added.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant v-ski.
SpecificityRecognizes Ski protein. Species Crossreactivity: human, mouse, rat, chicken, Xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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