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Anti -SKI (Sarcoma Viral Oncogene Homolog, Avian, c-SKI, SKV, v-Ski)
Anti -SKI (Sarcoma Viral Oncogene Homolog, Avian, c-SKI, SKV, v-Ski)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IC |
|
| SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc. | | | Catalog # | S1013-89N | | Applications | Suitable for use in Immunocytochemistry, Immunoprecipitation, and Western Blot. Other applications not tested. | | Recommended Dilution | Immunocytochemistry: 1-10ug/ml | | Western Blot: 1-5ug/ml | | Immunoprecipitation: 1-5ug | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9L649 | | Host | Mouse | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.4. No preservative added. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant v-ski. | | Specificity | Recognizes Ski protein. Species Crossreactivity: human, mouse, rat, chicken, Xenopus. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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