Anti -SKP1 (S-phase Kinase-associated Protein 1, S-phase Kinase-associated Protein 1A,
SKP1A, Cyclin A/CDK2-associated Protein p19, EMC19, MGC34403, Organ of Corti Protein 2,
OCP 2, OCP2, OCP-2, OCP II, OCP-II Protein, p19A, p19skp1, RNA Polymerase II Elongatio
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IH FC |
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| SKP1 (S-phase kinase-associated protein 1) is a core component of the Skp1-Cullin-F-box (SCF) ubiquitin ligase protein complex. It mediates the ubiquitination of proteins involved in cell cycle progression, transcriptional regulation, and signal transduction. Among the components | | | of the SCF complexes, SKP1 is an adaptor between one of the variable F-box proteins and Cullin (1). Independent of its function as a part of the SCF complex, SKP1 also functions in mitotic exit and cytokinesis. A possible contribution to the function of SKP1 in the mitotic exit is its physical interaction with Bfa1, a key negative regulator of the mitotic exit network (2). SKP1 also plays a crucial role in proper chromosomal segregation, which is required for the maintenance of | | | euploidy and suppression of transformation (3). | | | | | | Applications: | | | Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. | | | Catalog # | S1014-15E | | Recommended Dilution | Flow Cytometry: 1:50 | | Western Blot: 1:1000-1:2000 | | Immunohistochemistry: 1:100-1:250 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H509 | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide and 0.05% BSA. | | Purity | Supernatant | | Immunogen | A synthetic peptide corresponding to residues in human SKP1. | | Specificity | Recognizes human SKP1. Species Crossreactivity: Mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Cyclin A/CDK2-associated p19 |
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Download Specifications for Anti -SKP1 (S-phase Kinase-associated Protein 1, S-phase Kinase-associated Protein 1A, SKP1A, Cyclin A/CDK2-associated Protein p19, EMC19, MGC34403, Organ of Corti Protein 2, OCP 2, OCP2, OCP-2, OCP II, OCP-II Protein, p19A, p19skp1, RNA Polymerase II Elongatio |
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