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You are here:Home » Antibodies » Antibodies-T Cells » Anti -SLP-76 (lymphocyte cytosolic protein 2, SH2 domain containing leukocyte protein of 76kD, Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76kD, SLP76, SLP-76 tyrosine phosphoprotein)

Anti -SLP-76 (lymphocyte cytosolic protein 2, SH2 domain containing leukocyte protein of
76kD, Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76kD,
SLP76, SLP-76 tyrosine phosphoprotein)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP
SLP-76 is an adapter protein which is rapidly tyrosine phosphorylated following ligation of the T-cell Receptor. SLP 76 has an SH2 domain, a proline-rich region, and numerous putative tyrosine phosphorylation sites. In addition, SLP-76 binds GRB2 through a 20 amino acid stretch in the proline-rich region of SLP76. Overexpression of SLP 76 results in greatly augmented IL-2 production. SLP-76 therefore appears to play an important role in the signaling pathways involved in T-cell activation.
Detects SLP-76 (SH2 domain containing Leukocyte Protein) of 76kD, a hematopoietic cell-specific adapter protein which intereacts with other signaling molecules through amino-terminal phosphotyrosine residues, a central proline-rich region and a carboxyl-terminal Src homology 2 domain (SH2).
Catalog #S1014-20B
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionsWestern Blot: 1:500-1:1000 detected SLP-76 on 10ug of RAW 264 lysates.
Optimal dilutions to be determined by the researcher.
Positive ControlRAW264 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No9H275
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.08% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenBALB/c-derived hybridoma (NM_005565.3).
Cellular LocalizationCytoplasm (Probable).
SpecificityRecognizes human SH2 (Src homology 2) domain-Leukocyte Protein of ~76kD. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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