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Anti -SLP-76 (LCP2, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) Lymphocyte cytosolic protein 2, SH2 domain-containing leucocyte protein of 76kD, SH2 domain-containing leukocyte protein of 76kD,SLP-76 tyrosine phosphoprotein
Anti -SLP-76 (LCP2, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte
protein of 76kDa) Lymphocyte cytosolic protein 2, SH2 domain-containing leucocyte protein
of 76kD, SH2 domain-containing leukocyte protein of 76kD,SLP-76 tyrosine phosphoprotein
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B |
|
| SLP-76 is a 533aa, 76kD tyrosine phosphorylated intracellular docking protein with a single SH2 recognition domain. It is expressed in T cells, platelets, neutrophils, NK and mast cells, and is required for progression of T cells to double positive stage in the thymus. Tyrosine phosphorylation is required for interaction with the signaling proteins VAV, NCK, PLC , ITK, and | | | ZAP70. SLP-76 may be phosphorylated by ZAP70 leading to NF-AT and IL2 gene activation. | | | Human SLP-76 shares 83% and 85% aa sequence identity with mouse and rat SLP-76, | | | respectively. | | | Catalog # | S1014-20R | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1.0ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9H180 | | Host | Mouse | | Source | Human | | Concentration | ~500ug/ml | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant human PP4 aa1-533; Q13094 (E. coli). | | Specificity | Recognizes human SLP-76 at ~90kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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