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You are here:Home » Antibodies » Abs to Autoimmune » Anti -Sm (Smith) Antigen

Anti -Sm (Smith) Antigen

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Specifications

Clone Host Grade Applications
Polyclonal Human Serum E
The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE.
Catalog #S1014-25A
ApplicationsSuitable for use in ELISA and Immunodiffusion. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
IsotypeIgG
HostHuman
SourceHuman
ConcentrationNot Determined
FormSupplied as a lyophilized powder from PBS, pH 7.2, 0.02% sodium azide. Reconstitute with 2ml sterile ddH2O.
PuritySerum
ImmunogenHuman Sm antigen from human plasma
SpecificityRecognizes human Sm antigen. Shows the Sm precipitate band when tested using double immunodiffusion against rabbit thymus extract. Anti-RNP precipitant is detected. Exhibits no reactivity when tested against purified SSB, Scl-70 and Jo-1 antigens. Anti-RNP and low levels of anti-SSA activity are detected.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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