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Specifications

Clone Host Grade Applications Polyclonal Human Serum E

The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE.
Catalog #	S1014-25A
Applications	Suitable for use in ELISA and Immunodiffusion. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Human
Source	Human
Concentration	Not determined
Form	Supplied as a lyophilized powder from PBS, pH 7.2, 0.02% sodium azide. Reconstitute with 2ml sterile ddH2O.
Purity	Serum
Immunogen	Human Sm antigen from human plasma
Specificity	Recognizes human Sm antigen. Shows the Sm precipitate band when tested using double immunodiffusion against rabbit thymus extract. Anti-RNP precipitant is detected. Exhibits no reactivity when tested against purified SSB, Scl-70 and Jo-1 antigens. Anti-RNP and low levels of anti-SSA activity are detected.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.