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You are here:Home » Antibodies » Abs to Smad Proteins » Anti -SMAD3, phosphorylated (Ser425) (Mothers Against Decapentaplegic Homolog 3, Mothers Against DPP Homolog 3, MAD Homolog 3, Mad3, SMAD Family Member 3, SMAD 3, Smad3, JV15-2, MADH3)

Anti -SMAD3, phosphorylated (Ser425) (Mothers Against Decapentaplegic Homolog 3, Mothers
Against DPP Homolog 3, MAD Homolog 3, Mad3, SMAD Family Member 3, SMAD 3, Smad3, JV15-2,
MADH3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Smad3 is a 50kD transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase, functioning in cell proliferation, differentiation and development. Upon stimulation, Smad3 oligomerizes with Smad4 and translocates into the nucleus and binds to DNA and transcription factors.
Catalog #S1014-53X
Smad3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes.
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry:1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human Smad3 around the phosphorylation site of serine 425 (C-S-S-V-SP).
SpecificityRecognizes human Smad3, phosphorylated at Ser425. Species Cross-Reactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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