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Anti -Smad3 (Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma)
Anti -Smad3 (Small Mothers Against Decapentaplegic Deleted in Pancreatic Carcinoma)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP IH IC |
|
| SMAD3, a receptor regulated SMAD (R-SMAD) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is estimated to account for at least 80% of all TGF-beta-mediated response. Activated type I receptor phosphorylates receptor-activated SMADS (RSMADS) at their c-terminal two extreme serines in the SSXS motif. The phosphorylated R-SMAD translocate into nucleus, where they regulate transcription of target genes. SMAD3 signal transduction appears to be important in the rgulation of muscle-specific genes. Loss of SMAD3 is a feature of pediatric T-cell lymphoblastic leukemia, while upregulation of SMAD3 may be responsible for TGFB hyperresponsiveness observed in scleroderma. | | | Catalog # | S1014-53Z | | Applications | Suitable for use in Western Blot, Immunohistochemistry, Immunohistochemistry-M, | | Immunocytochemistry, Immunoprecipitation.. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:10000 | | Immunohistochemistry: 1:100-1:250 | | Immunohistochemistry-M: 1:100-1:250 | | Immunocytochemistry: 1:100-1:250 | | Immunoprecipitation: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Clone No | 11C183 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as liquid in PBS, 0.09% sodium azide. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to the internal region of human Smad3. | | Specificity | Recognizes human SMAD3. Species Crossreactivity: rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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