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You are here:Home » Antibodies » Abs to Smad Proteins » Anti -SMAD4 (MADH4, JIP, DPC4, SMAD4, MAD, Mothers Against Decapentaplegic Homolog 4 (Drosophila), Mothers Against Decapentaplegic, Drosophila, Homolog of, 4, MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 4)

Anti -SMAD4 (MADH4, JIP, DPC4, SMAD4, MAD, Mothers Against Decapentaplegic Homolog 4
(Drosophila), Mothers Against Decapentaplegic, Drosophila, Homolog of, 4, MAD (Mothers
Against Decapentaplegic, Drosophila) Homolog 4)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IC
SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Catalog #S1014-54C1
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with 1.2% sodium acetate. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10K345
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from 1.2% sodium acetate, 2mg BSA, 0.01mg sodium azide. Reconstitute with 1.2% sodium acetate, PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant human Smad4.
SpecificityRecognizes human Smad4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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