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Abs to Smad Proteins
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Anti -SMAD5 (Mothers Against Decapentaplegic Homolog 5, MAD Homolog 5, Mothers Against DPP Homolog 5, JV5-1, SMAD Family Member 5, SMAD 5, hSmad5, MADH5)
Anti -SMAD5 (Mothers Against Decapentaplegic Homolog 5, MAD Homolog 5, Mothers Against DPP
Homolog 5, JV5-1, SMAD Family Member 5, SMAD 5, hSmad5, MADH5)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of TGFb/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF-b and activin-mediated growth modulation. Smad4 has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFb signaling by interfering with TGFb-mediated phosphorylation of other Smad family members. | | | Catalog # | S1014-55G6 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1-4ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa252 of human Smad5. | | Specificity | Recognizes human Smad5 at ~60kD. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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