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You are here:Home » Antibodies » Abs to SNX (Sorting Nexin) Proteins » Anti -SNX2 (Sorting Nexin 2, Sorting Nexin-2, MGC5204, Transformation-related Gene 9 Protein, TRG9, TRG-9)

Anti -SNX2 (Sorting Nexin 2, Sorting Nexin-2, MGC5204, Transformation-related Gene 9
Protein, TRG9, TRG-9)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Snx2 is a signaling protein belonging to the sorting nexin family and characterized by the presence of a 100aa region known as the phox (PX) homology domain (a phosphoinositide binding domain). As a transport carrier SNX2 is involved in several stages of intracellular trafficking of proteins and also in the EGFR signaling pathway. The retromer complex that is composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2, is required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Though Snx2 associates with formin-binding protein 17, its function is yet unknown. It may form oligomeric complexes with itself as well as with other family members Snx1, Snx1A, and Snx4, but not with Snx3 and is ubiquitously expressed in most tissues, including peripheral leukocytes.
Catalog #S1014-97B1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.25-0.5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlMouse placenta lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa120-170 of human Snx2.
SpecificityRecognizes human Snx2. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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