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You are here:Home » Biochemicals » Biochem-Molecular Biology » SMER28 (Small-Molecule Enhancer of Rapamycin-28, 6-Bromo-4-allylaminoquinazoline)

SMER28 (Small-Molecule Enhancer of Rapamycin-28, 6-Bromo-4-allylaminoquinazoline)

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Specifications

Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington’s Disease (HD).
Catalog #S1015-15
SolubilityDMSO (~8mg/ml), EtOH (~2mg/ml)
Molecular Weight~264.12
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number307538-42-7
Molecular FormulaC H BrN
Molecular Weight~264.12
Purity~98% (TLC)
FormSupplied as an off-white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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