Anti -SOCS 1 (Suppressor of Cytokine Signalling 1, SOCS1, SOCS-1, Cytokine Inducible SH2
Protein 1, CISH1, Janus Kinase Binding Protein, JAK-binding Protein, JAB, STAT-induced
STAT Inhibitor 1, SSI1, SSI-1, TEC-interacting Protein 3, TIP3, TIP-3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP |
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| The Suppressor of Cytokine Signaling (SOCS) family of proteins acts in a classic negative feedback loop to regulate cytokine signal transduction. SOCS-1, also designated Janus kinase [JAK] binding protein (JAB), or STAT-induced STAT inhibitor (SSI-1), is a 24kD protein containing an SH2 domain. SOCS-1 inhibits both IL-6-induced receptor phosphorylation and STAT activation. SOCS-1 is also 45 induced by and inhibits the signaling action of IL-3, IL-4, 1 2 3 4kD 97 66 LLIF, prolactin, and erythropoietin. Additionally, SOCS-1 can associate with all 4 JAK family kinases, and is an important regulator of the JAK-STAT signaling pathway. SOCS-1 is found primarily in thymocytes, where it plays a key role in the negative regulation of IFN-g signaling and T cell differentiation. | | | Catalog # | S1040-01K | | Applications | Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Western Blot: 0.1ug/ml | | Immunoprecipitation: 10ug/200ul of cell extract from 5x10e6 cells. | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Sp2/0 with C57BL/6 myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11n174 | | Host | Mouse | | Source | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 100ul PBS, pH 7.2, 50% glycerol. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant corresponding to aa2-78 from mouse GST-SOCS-1. | | Specificity | Recognizes mouse SOCS-1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -SOCS 1 (Suppressor of Cytokine Signalling 1, SOCS1, SOCS-1, Cytokine Inducible SH2 Protein 1, CISH1, Janus Kinase Binding Protein, JAK-binding Protein, JAB, STAT-induced STAT Inhibitor 1, SSI1, SSI-1, TEC-interacting Protein 3, TIP3, TIP-3) |
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