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You are here:Home » Antibodies » Abs to SOCS » Anti -SOCS 1 (Suppressor of Cytokine Signalling 1, SOCS1, SOCS-1, Cytokine Inducible SH2 Protein 1, CISH1, Janus Kinase Binding Protein, JAK-binding Protein, JAB, STAT-induced STAT Inhibitor 1, SSI1, SSI-1, TEC-interacting Protein 3, TIP3, TIP-3)

Anti -SOCS 1 (Suppressor of Cytokine Signalling 1, SOCS1, SOCS-1, Cytokine Inducible SH2
Protein 1, CISH1, Janus Kinase Binding Protein, JAK-binding Protein, JAB, STAT-induced
STAT Inhibitor 1, SSI1, SSI-1, TEC-interacting Protein 3, TIP3, TIP-3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP
The Suppressor of Cytokine Signaling (SOCS) family of proteins acts in a classic negative feedback loop to regulate cytokine signal transduction. SOCS-1, also designated Janus kinase [JAK] binding protein (JAB), or STAT-induced STAT inhibitor (SSI-1), is a 24kD protein containing an SH2 domain. SOCS-1 inhibits both IL-6-induced receptor phosphorylation and STAT activation. SOCS-1 is also 45 induced by and inhibits the signaling action of IL-3, IL-4, 1 2 3 4kD 97 66 LLIF, prolactin, and erythropoietin. Additionally, SOCS-1 can associate with all 4 JAK family kinases, and is an important regulator of the JAK-STAT signaling pathway. SOCS-1 is found primarily in thymocytes, where it plays a key role in the negative regulation of IFN-g signaling and T cell differentiation.
Catalog #S1040-01K
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 0.1ug/ml
Immunoprecipitation: 10ug/200ul of cell extract from 5x10e6 cells.
Optimal dilutions to be determined by the researcher.
HybridomaSp2/0 with C57BL/6 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11n174
HostMouse
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in 100ul PBS, pH 7.2, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant corresponding to aa2-78 from mouse GST-SOCS-1.
SpecificityRecognizes mouse SOCS-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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