Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to SOCS » Anti -SOCS1, CT (Suppressor of Cytokine Signaling 1, Tec-interacting Protein 3, TIP-3, STAT-induced STAT Inhibitor 1, SSI-1, JAK-binding Protein, JAB, Suppressor of Cytokine Signaling 1, SOCS-1, SSI1, TIP3)

Anti -SOCS1, CT (Suppressor of Cytokine Signaling 1, Tec-interacting Protein 3, TIP-3,
STAT-induced STAT Inhibitor 1, SSI-1, JAK-binding Protein, JAB, Suppressor of Cytokine
Signaling 1, SOCS-1, SSI1, TIP3)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Suppressors of cytokine signaling (SOCS) protein family includes eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src-homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous C-terminal 40aa long sequence that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. SOCS-1 is 211aa long and shares sequence similarity with SOCS-3. Its expression in many tissues is induced by elevated levels of IL-2, IL-3, IL- 6, IL-13, LIF, GM-CSF, IFNg, GH, and prolactin. SOCS-1 targets Janus activated kinases 1-3 (JAK1-3) and tyrosine kinases 2 (TYK2). These events negatively regulate family of signal transducer and activator of transcription (STAT) proteins. For example, SOCS-1 binds to Y1007 residue of JAK2 and blocks its phosphorylation activity that does not allow activation of STAT3.
Catalog #S1040-01V
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.1-1ug/ml
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide from near the C-terminus of human SOCS-1.
SpecificityRecognizes human SOCS-1. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links