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You are here:Home » Antibodies » Abs to SOCS » Anti -SOCS1 (Suppressor of Cytokine Signaling 1, Tec-interacting Protein 3, TIP-3, STAT-induced STAT Inhibitor 1, SSI-1, JAK-binding Protein, JAB, Suppressor of Cytokine Signaling 1, SOCS-1, SSI1, TIP3)

Anti -SOCS1 (Suppressor of Cytokine Signaling 1, Tec-interacting Protein 3, TIP-3,
STAT-induced STAT Inhibitor 1, SSI-1, JAK-binding Protein, JAB, Suppressor of Cytokine
Signaling 1, SOCS-1, SSI1, TIP3)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins, which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
Catalog #S1040-01X
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:4000
Western Blot: 1-3ug/ml
Immunohistochemistry (Paraffin): 2-3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-VLRDYLSSFPFQI, from SOCS1, at C-terminal (NP_003736.1).
SpecificityRecognizes human SOCS1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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