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You are here:Home » Antibodies » Abs to SOCS » Anti -SOCS 3 (Suppressor of Cytokine Signalling 3, Janus kinase (JAK) binding protein 3, STAT-induced STAT inhibitor 3, SSI 3)

Anti -SOCS 3 (Suppressor of Cytokine Signalling 3, Janus kinase (JAK) binding protein 3,
STAT-induced STAT inhibitor 3, SSI 3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
SOCS3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohnís Disease. SOCS3 expression has also been shown to affect IFN alpha sensitivity in tumor studies.
Catalog #S1040-03E
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:50-1:250, detects a band of ~30kD in Hela cell lysates.
Optimal dilution determined by the researcher.
Recommended Secondary ReagentsI1904-65W: IgG, F(abí)2 (HRP) Pab RbxMo
I1904-66C: IgG, F(abí)2, X-Adsorbed (HRP) Pab RbxMo
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No6A463
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide before the addition of glycerol to 40%.
PurityPurified by protein A affinity chromatography.
ImmunogenFull - length SOCS3 protein.
SpecificityRecognizes suppressor of cytokine signaling 3 (SOCS3), a 30kDa member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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