Anti -SOCS3, Induced (Suppressor of Cytokine Signaling 3, SOCS-3, Cytokine-inducible SH2
Protein 3, CIS-3, SSI-3, CIS3, SSI3, STAT-induced STAT Inhibitor 3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IH |
|
| Suppressors of cytokine signaling (SOCS) protein family include eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src-homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous C-terminal 40aa long sequence that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. SOCS-3 is 225aa long and shares sequence similarity with SOCS- 1. Its expression in many tissues is induced by elevated levels of IL-1, IL-4, IL-6, LIF, GM-CSF, IFNg, GH, EPO, leptin, prolactin, and other cytokines. However, SOCS-3 is found mostly in lungs, spleen, and fat. SOCS-3 targets Janus activated kinases similar to SOCS-1, but with lower affinity and does not block their activity. In addition, SOCS-3 binds phosphorylated tyrosine (Y) residues of various receptors: Y759 of gp130, Y333/338 of GHR, and Y985,1077 of leptin receptor. | | | Catalog # | S1040-03T | | Applications | Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:200-1:500 | | Immunohistochemistry: 1:100-1:200 | | Immunoprecipitation: 1:50-1:200 extract from 10e7 cells | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the C-terminus of human SOCS-3. | | Specificity | Recognizes human SOCS-3. Species sequence homology: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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