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You are here:Home » Antibodies » Abs to SOCS » Anti -SOCS3, Induced (Suppressor of Cytokine Signaling 3, SOCS-3, Cytokine-inducible SH2 Protein 3, CIS-3, SSI-3, CIS3, SSI3, STAT-induced STAT Inhibitor 3)

Anti -SOCS3, Induced (Suppressor of Cytokine Signaling 3, SOCS-3, Cytokine-inducible SH2
Protein 3, CIS-3, SSI-3, CIS3, SSI3, STAT-induced STAT Inhibitor 3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH
Suppressors of cytokine signaling (SOCS) protein family include eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src-homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous C-terminal 40aa long sequence that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. SOCS-3 is 225aa long and shares sequence similarity with SOCS- 1. Its expression in many tissues is induced by elevated levels of IL-1, IL-4, IL-6, LIF, GM-CSF, IFNg, GH, EPO, leptin, prolactin, and other cytokines. However, SOCS-3 is found mostly in lungs, spleen, and fat. SOCS-3 targets Janus activated kinases similar to SOCS-1, but with lower affinity and does not block their activity. In addition, SOCS-3 binds phosphorylated tyrosine (Y) residues of various receptors: Y759 of gp130, Y333/338 of GHR, and Y985,1077 of leptin receptor.
Catalog #S1040-03T
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:200-1:500
Immunohistochemistry: 1:100-1:200
Immunoprecipitation: 1:50-1:200 extract from 10e7 cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminus of human SOCS-3.
SpecificityRecognizes human SOCS-3. Species sequence homology: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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