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You are here:Home » Antibodies » Abs to SOCS » Anti -SOCS 5 (Suppressor of Cytokine Signaling 5, SOCS5, SOCS-5, Cytokine-inducible SH2-containing Protein 5, CISH5, Cytokine-inducible SH2 Protein 6, CIS6, CIS-6, CISH6, KIAA0671)

Anti -SOCS 5 (Suppressor of Cytokine Signaling 5, SOCS5, SOCS-5, Cytokine-inducible
SH2-containing Protein 5, CISH5, Cytokine-inducible SH2 Protein 6, CIS6, CIS-6, CISH6,
KIAA0671)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Catalog #S1040-05L
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:64,000
Western Blot: 0.3-1ug/ml, observed in lysates of cell line Molt4 on ~65kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to DKVGKMWNNFK-C, from human SOCS5, at N-terminal (NP_054730.1).
SpecificityRecognizes human SOCS5. Species sequence homology: Bovine, mouse, porcine and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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