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You are here:Home » Antibodies » Abs to SOCS » Anti -SOCS6, ID (Suppressor of Cytokine Signaling 6, SOCS-6, Cytokine-inducible SH2 Protein 4, CIS-4, Suppressor of Cytokine Signaling 4, SOCS-4, CIS4, SOCS4)

Anti -SOCS6, ID (Suppressor of Cytokine Signaling 6, SOCS-6, Cytokine-inducible SH2
Protein 4, CIS-4, Suppressor of Cytokine Signaling 4, SOCS-4, CIS4, SOCS4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Suppressors of cytokine signaling (SOCS) protein family includes eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src-homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous C-terminal 40aa long sequence that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. SOCS-6 is one of the least studied members of the SOCS family. It is 535aa long and has 56% sequence identity with SOCS-7 in region (1-2, 7). Recent studies revealed that SOCS-6 does not interact with Janus kinase family proteins. However, it was found that SOCS-6 binds to KIT membrane region and negatively regulates receptor tyrosine kinases. In addition, studies revealed that SOCS-6 binds to insulin receptor substrate-2, and -4 (IRS-2, and 4) and inhibits downstream signaling.
Catalog #S1040-06K
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.1-1ug/ml
Western Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the internal sequences of human SOCS-6.
SpecificityRecognizes human SOCS-6. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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