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Anti -SOCS7, ID (Suppressor of Cytokine Signaling 7, SOCS-7, Nck Ash and Phospholipase C gamma-binding Protein, Nck-associated Protein 4, NAP4, NAP-4, NCKAP4)
Anti -SOCS7, ID (Suppressor of Cytokine Signaling 7, SOCS-7, Nck Ash and Phospholipase C
gamma-binding Protein, Nck-associated Protein 4, NAP4, NAP-4, NCKAP4)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Suppressors of cytokine signaling (SOCS) protein family includes eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src- homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous C-terminal 40aa long sequence that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. SOCS-7 is one of the least studied members of the SOCS family. It is 581aa long and has 56% sequence identity with SOCS-6 in SH 2 region. SOCS-7 is the only member of the SOCS family that contains nuclear localization signal and proline-rich regions; specifically, it can interact with adaptor molecules Nck and Ash. It is predominantly expressed in the testis and brain. Similar to SOCS-6, it binds to IRS-2 and IRS-4 proteins. In addition, SOCS-7 interacts with actin, vinexin, and STAT5. | | | Catalog # | S1040-07E | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:200-1:500 | | ELISA: 1:5000-1:20,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the intermediate region of human SOCS-7. | | Specificity | Recognizes human SOCS-7. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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