SorCS2 is a family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. It is noted that all mammalian VPS10 domains carry an N-terminal signal peptide for translocation into the endoplasmic reticulum. The greatest similarity between the receptors is found in the C-terminal parts of the VPS10 domains, which harbor 12 cysteine residues with a characteristic spacing conserved in all VPS10 proteins from yeast to man. SorCS2 is a single-pass type I membrane protein that is highly expressed in brain and kidney. It is also detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.