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S5363-01 Mouse Anti-Sorcin (SRI, 22kD Protein, CP-22, V19) (Azide Free)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
P30626
Isotype
IgG2a,k
Clone Number
11C791
Grade
Purified
Applications
E WB
Crossreactivity
Hu
Accession #
AAH11025
Shipping Temp
Blue Ice
Storage Temp
-20°C
Notes
Preservative Free

Sorcin is a 198aa, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilutions
Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Full length recombinant protein corresponding to aa1-199 from human Sorcin with GST tag. MW of GST tag alone is 26kD.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
Purity
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human Sorcin.
Conjugates
Pricing
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