Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Lectins » Anti -Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (Specific ICAM-3 Grabbing Nonintegrin R1, SIGN-R1, CD209 antigen-like Protein B)

Anti -Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (Specific ICAM-3
Grabbing Nonintegrin R1, SIGN-R1, CD209 antigen-like Protein B)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Rat Purified IH FC
SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in some strains, in the peritoneal cavity. Does not react with macrophages in other regions of the spleen, such as CD169+ marginal metallophils and F4/80+ red pulp macrophages. MZM of the spleen are involved in the clearance of polysaccharides. Mouse SIGN-R1 is a C-type lectin, like DC-SIGN which is expressed on human dendritic cells (DCs). However, mouse SIGN-R1 itself is not expressed on DCs. SIGN-R1 exists in an aggregated form, resistant to dissociation into monomers upon boiling in SDS under reducing conditions. SIGN-R1 mediates the uptake of encapsulated organisms and may be an important mediator for the uptake of microbes in both spleen and lymph node, particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody. Therefore, the monoclonal antibody can be used to study the uptake of polysaccharides by macrophages.
Catalog #S5370-90
ApplicationsSuitable for use in Immunohistochemistry and Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:50.
Immunohistochemistry (frozen, paraffin): 1:50.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone NoER-TR9
HostRat
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid.
PurityPurified
ImmunogenER-TR9 reacts with murine SIGN-related 1 (SIGN-R1).
SpecificityRecognizes murine SIGN-related 1 (SIGN-R1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links