Anti -Spectrin, alpha (Spectrin alpha Chain, Spectrin alpha Chain Brain, Spectrin
Non-erythroid alpha Chain, Alpha Fodrin, Alpha II Spectrin, FLJ44613, Fodrin alpha Chain,
Non-erythrocytic Spectrin alpha, Spectrin alpha Non-erythrocytic 1, SPTAN1, SPTA2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP IH IC |
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| Alpha Fodrin is a member of the spectrin family of widely distributed filamentous proteins that form a supporting and organizing scaffold for cell membranes (1). Non-erythroid alpha spectrin, also called Alpha Fodrin, is a major cortical cytoskeletal protein that is implicated in the establishment of specialized membrane-cytoskeletal domains in differentiating cells (2, 3). Cleavage of Alpha Fodrin accompanies apoptosis, induced by activation via the CD3/T cell receptor complex, ligation of the Fas (CD95) molecule and other Fas-expressing cells; it may also be induced by the treatment of cells with staurosporine, dexamethasone, or synthetic ceramide (4). The major products of cleavage are amino-terminal and carboxy-terminal fragments. Antibodies against Alpha Fodrin are observed in diseases characterized by chronic apoptosis (5, 6). | | | Catalog # | S5379-96G | | Applications | Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Western Blot: 1:10,000-1:50,000 | | Immunohistochemistry (Paraffin): 1:500-1:1000 | | Immunocytochemistry: 1:250-1:500 | | Immunoprecipitation: 1:10-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 10D40 | | Host | Rabbit | | Source | Human | | Concentration | Not Determined | | Form | Supplied as liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol. | | Purity | Supernatant | | Immunogen | A synthetic peptide corresponding to residues in human Spectrin, alpha . | | Specificity | Recognizes human Spectrin, alpha at 285, 150kD. Species Crossreactivity: rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Spectrin, alpha (Spectrin alpha Chain, Spectrin alpha Chain Brain, Spectrin Non-erythroid alpha Chain, Alpha Fodrin, Alpha II Spectrin, FLJ44613, Fodrin alpha Chain, Non-erythrocytic Spectrin alpha, Spectrin alpha Non-erythrocytic 1, SPTAN1, SPTA2) |
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