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You are here:Home » Antibodies » Abs to Spectrin » Anti -Spectrin, beta1 (Spectrin beta 1, Beta I Spectrin, Beta Spectrin, HSpTB1, Spectrin beta Chain Erythrocyte, Spectrin beta Erythrocytic (Includes Spherocytosis Clinical Type I), SPTB, SPTB1)

Anti -Spectrin, beta1 (Spectrin beta 1, Beta I Spectrin, Beta Spectrin, HSpTB1, Spectrin
beta Chain Erythrocyte, Spectrin beta Erythrocytic (Includes Spherocytosis Clinical Type
I), SPTB, SPTB1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B IF
Spectrin (Sp), the most abundant of the erythrocyte membrane skeleton proteins, helps these cells maintain their characteristic biconcave shape while remaining flexible and elastic. Erythrocyte Sp is a heterodimer composed of a 280kD alpha subunit and a 246kD beta subunit which associate in a side-to-side, antiparallel configuration to form a 100 nm rod-like structure. Sp in other tissues may be composed of distinct but homologous alpha and beta subunits, sometimes referred to as fodrin. A newly introduced nomenclature designates the Sp subunits of the erythrocyte as alpha-1 and beta-1, and the fodrin subunits as alpha-2 and beta-2. Alternatively spliced forms of each are designated as epsilon-1, epsilon-2, etc. (e.g. beta-1 epsilon-1).
Catalog #S5380-12A
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9E720
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
PurityAscites
ImmunogenPurified human erythrocyte beta-1 spectrin.
SpecificityDetects spectrin from erythrocytes, brain and muscle cells. This antibody has been shown to specifically detect the two known alternatively spliced forms of spectrin, beta-1 epsilon-1, present in erythrocytes, and beta-1 epsilon-2, present in nerve and striated muscle cells. It does not crossreact with alpha-2 spectrin or either of the fodrin subunits. Species Crossreactivity: Crossreacts with Human, Rat and Mouse. Not yet tested in other species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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